Table 1.
Summary of clinical, endoscopic, and histopathological characteristics of the total 271 patients, and the total 208 patients with submucosal invasion thickness ≥250µm, and the 170 tissue microarray patients with submucosal invasion thickness ≥250µm
| Characteristics | Total cases (n=271), no. (%) |
Cases with submucosal invasion thickness ≥250µm (n=208), no. (%) |
Tissue microarray cases with submucosal invasion thickness ≥250µm (n=170), no. (%) |
Pa | Pb | |
|---|---|---|---|---|---|---|
| Clinical variables | ||||||
| Sex | Male | 197 (73) | 152(73) | 124(73) | 0.955 | 0.976 |
| Female | 74 (27) | 56(27) | 46(27) | |||
| Age | <60 years | 167 (62) | 127(61) | 106(62) | 0.878 | 0.797 |
| ≥60 years | 104 (38) | 81(39) | 64(38) | |||
| Symptoms | No symptoms | 14 (5) | 8(4) | 5(3) | 0.263 | 0.631 |
| Others | 257 (95) | 200(96) | 165(97) | |||
| Endoscopic variables | ||||||
| Tumor location | Cervical | 2 (1) | 2(1) | 2(1) | 0.756 | 0.995 |
| Upper thoracic | 43 (16) | 39(18) | 33(19) | |||
| Middle thoracic | 187 (69) | 139(67) | 112(66) | |||
| Lower thoracic | 39 (14) | 28(14) | 23(14) | |||
| Tumor size (measured endoscopically) | <2cm | 70 (26) | 44(21) | 37(22) | 0.332 | 0.886 |
| ≥2cm | 201 (74) | 164(79) | 133(78) | |||
| Macroscopic type | Erosive | 85 (31) | 45(22) | 32(19) | 0.071 | 0.956 |
| Papillary | 32 (12) | 26(13) | 22(13) | |||
| Plaque-like | 120 (44) | 106(51) | 92(54) | |||
| Ulcerative | 15 (6) | 14(7) | 10(6) | |||
| Intraluminal mass | 19 (7) | 17(8) | 14(8) | |||
| Standard histopathological variables | ||||||
| Invasion depth level | m2 | 22 (8) | NA | NA | <0.001 | 0.875 |
| m3 | 30 (11) | NA | NA | |||
| sm1 | 23 (9) | 12(6) | 10(6) | |||
| sm2 | 55 (20) | 55(26) | 41(24) | |||
| sm3 | 141 (52) | 141(68) | 119(70) | |||
| Degree of differentiation | Well | 49 (18) | 42(20) | 36(21) | 0.650 | 0.934 |
| Moderate | 104 (38) | 77(37) | 68(40) | |||
| Poor | 80 (30) | 57(27) | 40(24) | |||
| Basaloid | 25 (9) | 24(12) | 19(11) | |||
| Sarcomatoid | 13 (5) | 8(4) | 7(4) | |||
| Angiolymphatic invasion | No | 220 (81) | 161(77) | 132(78) | 0.368 | 0.955 |
| Yes | 51 (19) | 47(23) | 38(22) | |||
| Multicentric invasive lesions | No | 248 (92) | 194(93) | 160(94) | 0.312 | 0.736 |
| Yes | 23 (8) | 14(7) | 10(6) | |||
| Glandular involvement by high-grade | No | 198 (73) | 156(75) | 129(76) | 0.510 | 0.843 |
| dysplasia/carcinoma-in-situ | Yes | 73 (27) | 52(25) | 41(24) | ||
| Measured histopathological variables | ||||||
| Tumor thickness | <3000µm | 98 (36) | 46(22) | 34(20) | <0.001 | 0.616 |
| ≥3000µm | 173 (64) | 162(78) | 136(80) | |||
| Submucosal invasion thickness | <2000µm | 156(58) | 93(45) | 71(42) | 0.005 | 0.565 |
| ≥2000µm | 115(42) | 115(55) | 99(58) | |||
| Diameter of largest invasive lesion | <2cm | 172 (63) | 112(54) | 90(53) | 0.034 | 0.861 |
| ≥2cm | 99 (37) | 96(46) | 80(47) | |||
| Lymph node metastasis | No | 218 (80) | 157(75) | 123(72) | 0.048 | 0.490 |
| Yes | 53 (20) | 51(25) | 47(28) | |||
| Immunohistochemial staining | ||||||
| P53 | − | NA | NA | 76(46) | NA | NA |
| + | NA | NA | 41(25) | |||
| ++ | NA | NA | 47(29) | |||
| CyclinD1 | − | NA | NA | 51(31) | NA | NA |
| + | NA | NA | 47(29) | |||
| ++ | NA | NA | 64(40) | |||
| EGFR | − | NA | NA | 59(36) | NA | NA |
| + | NA | NA | 53(32) | |||
| ++ | NA | NA | 52(32) | |||
| VEGF | − | NA | NA | 51(31) | NA | NA |
| + | NA | NA | 45(28) | |||
| ++ | NA | NA | 66(41) | |||
Abbreviation: NA, not associated
a
total 271 cases vs. 170 tissue microarray submucosal cases with submucosal invasion thickness ≥250µm
b
208 submucosal cases with submucosal invasion thickness ≥250µm vs. 170 tissue microarray submucosal cases with submucosal invasion thickness ≥250µm