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Newly identified accessory mutations and thumb subdomain polymorphisms. Histograms represent the frequencies of the indicated mutations among CRF01_AE and CRF07_BC sequences. Frequencies were expressed as percentages of the total CRF01_AE (N=84) or CRF07_BC (N=35) samples examined, and compared with the χ2 test or Fisher's exact test. “+” denoted statistically significant (p<0.05).
