Table 2.
Hemoglobin, Red Blood Cell Indices, and Iron Studies in HIV-Infected Children
| Baseline data | N | Mean (SD) | % Abnormal (95% CI) |
|---|---|---|---|
| Hemoglobin (g/dl)a | 299 | 11.2 (1.1) | 49.5 (43.7, 55.3) |
| Mean corpuscular volume (MCV) (fl)b | 299 | 73.4 (7.8) | 84.3 (79.7, 88.2) |
| Mean corpuscular hemoglobin (MCH) (pg)c | 298 | 24.1 (3.0) | 45.3 (39.6, 51.1) |
| Serum iron (μmol/liter) | 298 | 11.2 (5.6) | 38.3 (32.7, 44.0) |
| Total iron binding capacity (μmol/liter) | 298 | 53.2 (14.3) | 13.8 (10.1, 18.2) |
| Transferrin saturation (%) | 298 | 22.4 (12.1) | 15.1 (11.2, 19.7) |
| Abnormal≥3/5 parameters | 298 | — | 28.9 (23.8, 34.4) |
| Low Hb+abnormal≥3 parameters | 298 | — | 18.5 (14.2, 23.3) |
| Low ferritin+low Hb | 298 | — | 1.7 (0.5, 3.9) |
| Serum ferritin (SF), (μg/liter) | 298 | 78.3 (76.4) | |
| <10 μg/liter | 1.7 (0.6, 3.9) | ||
| <50 μg/liter | 39.6 (34.0, 45.4) | ||
| Serum C-reactive protein (CRP) ≥10 mg/liter | 177 | — | 11.3 (7.0, 16.9) |
| Iron deficiency anemia (IDA) using | |||
| SF< 10 μg/liter for all | 298 | 4 cases | 1.3 (0.4, 3.4) |
| SF<50 μg/liter for all | 298 | 24 cases | 8.1 (5.2, 11.7) |
| SF<10 μg/liter if CRP<10 mg/liter+ | 8 cases | 2.7 (1.2, 5.2) | |
| SF<50 μg/liter if CRP≥10 mg/liter | |||
a
Low hemoglobin (Hb) by age: children age<5 years,<11.0 g/dl; age 5–11 years, 11.5 g/dl: age 12–14 years,<12.0 g/dl.
b
MCV less than normal age-related values (<2 years=78 fl, 2–5 years=81 fl, ≥6 years=81 fl).
c
MCH less than normal age-related values (<2 years=23 pg, 2–5 years=24 pg, ≥6 years=25 pg).
One child had no iron study at week 0.
IDA, iron deficiency anemia was defined as low Hb+ abnormal≥3 parameters+ferritin criteria below cut-off level.