Table 3.
Thalassmia Traits and Diseases by Hb Typing and DNA Analysis Between Anemia and Nonanemia Groups
| DNA analysis | Total | Anemia N=148 | Non anemia N=151 | p-value |
|---|---|---|---|---|
| Nonthalassemia | 174 | 65 (43.9) | 109 (72.2) | <0.001 |
| Anemia of chronic diseasea | 62 | 62 (41.8) | 0 (0.0) | |
| Thalassemia trait | 116 | 74 (50.0) | 42 (27.8) | |
| α1-thalassemia (thal) trait | 9 | 7 (4.7) | 2 (1.3) | |
| α2-thalassemia trait | 31 | 21 (14.2) | 10 (6.6) | |
| HbCS trait | 12 | 7 (4.7) | 5 (3.3) | |
| HbE trait | 47 | 29 (19.6) | 18 (11.9) | |
| HbE trait+HbCS trait | 4 | 3 (2.0) | 1 (0.7) | |
| HbE trait+α2-thalassemia trait | 10 | 4 (2.7) | 6 (4.0) | |
| HbE trait+α1-thalassemia trait | 1 | 1 (0.7) | 0 (0.0) | |
| β-thalassemia trait | 1 | 1 (0.7) | 0 (0.0) | |
| β-thalassemia trait+α2-thalassemia trait | 1 | 1 (0.7) | 0 (0.0) | |
| Thalassemia diseases | 9 | 9 (6.1) | 0 (0.0) | |
| HbE disease | 7 | 7 (4.7) | 0 (0.0) | |
| HbH diseasesb | 2 | 2 (1.4) | 0 (0.0) |
a
Anemia of chronic disease (ACD)=62 cases after excluded three cases of IDA.
b
One HbA2ABartH and one HbCSA2ABartH.
Eight cases of IDA were in the anemia group (three cases in nonthalassemia, three cases in the HbE trait group, one case in HbE trait+HbCS trait, and one case in α2-thalassemia trait).