Table 1.

huOKT4 Reduces CD4 T Cells in Tissues Compared to Controls in Acute Infection

	CD3+CD4+		CD3+CD8+
	Control	huOKT4	Control	huOKT4
PBMC (cells/μl)	3.02±0.25	2.07±0.07*	3.05±0.27	3.44±0.20*
BAL (cells/lavagea)	6.05±0.47	5.10±0.34***	6.18±0.42	6.02±0.80
Hilar LN (cells/gm)	7.68±0.43	5.42±0.68***	7.51±0.41	6.61±0.45**
Involved lung (cell/gm)	5.57±1.17	4.56±0.58*	5.83±0.90	5.61±0.54

Samples obtained at necropsy.

^aLavage is 40 ml of saline.

Absolute numbers of cells (log transformed) mean±standard deviation: ^*p≤0.01, ^**p≤0.001, ^***p≤0.001, Student's t test.

PBMC, peripheral blood mononuclear cells; BAL, bronchoalveolar lavage; LN, lymph node.