Table 1.
Demographics and Drug Resistance-Related Mutations Within the Polymerase Domain of HIV-1 RT, Associated with Insertions or Deletions of One or Two Amino Acids Between Codons 67 and 69 (β3–β4 Loop)
| S. No. | HIV-1 RT insertion/deletion | Age/sex | Mode of transmision | CD4+count cells/μl | HAART exposure (months) | NRTI mutations | NNRTI mutations |
|---|---|---|---|---|---|---|---|
| 1 | Dipeptide (SG) insertion at 69 | 32/M | HT | 90 | 64 | M41L, T69Si, M184V | Y188L |
| 2 | 38/M | HT | 171 | 57 | M41L, D67E, T69Si, L74V, M184V, T215Y | K103KN, V108I, Y181C, H221Y | |
| 3 | Dipeptide (SS) insertion at 69 | 38/M | HT | 318 | 54 | M41L, T69Si, M184V, T215Y | Y188L, G190A |
| 4 | Dipeptide (ST) insertion at 69 | 37/M | HT | 38 | 81 | M41L, T69Si, M184V, T215Y | A98AG, Y188L |
| 5 | Dipeptide (VT) insertion at 69 | 45/M | HT | 180 | 52 | M41L, D67N, T69Si, L74V, M184V, T215Y | A98G, L100IL, K101KPQT, K103N, V108IV |
| 6 | D67 deletion | 30/F | HT | 115 | 65 | D67d, T69G, K70R, M184V, T215F, K219Q | Y188L |
| 7 | 39/M | HT | 166 | 72 | M41L, D67d, T69G, K70R, M184V, T215FY, K219E | V90I, A98G, V108I, Y181C, G190A | |
| 8 | T69 deletion | 29/M | HT | 123 | 39 | K65R, T69d, Q151M | K103N, Y181C |
| 9 | 14/F | BT | 150 | 40 | K65R, D67N, T69d, Q151M | V90I, V106M, Y181C | |
| 10 | 36/M | HT | 180 | 48 | K65R, T69d | A98AG, E138A, G190E, H221Y |
HT, heterosexual transmission; BT, blood transmission; RT, reverse transcriptase; HAART, highly active antiretroviral therapy; NRTI, nucleoside reverse transcriptase inhibitor; NNRTI, nonnucleoside reverse transcriptase inhibitor.