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. Author manuscript; available in PMC: 2012 Nov 23.
Published in final edited form as: Gastroenterology. 2008 Apr 16;135(2):660–670. doi: 10.1053/j.gastro.2008.04.009

Figure 1. αvβ6 integrin expression in livers of normal and fibrotic rats and mice, and in various liver cells.

Figure 1

Rate limiting β6 transcript levels as quantified by real time PCR in: (A) Rat livers after 6 weeks of BDL and livers of 8 wk old MDR2-/- mice, both normalized to their age-matched sham-operated and wildtype controls, respectively; data in the MDR2-/-mice are from ref.29; (B) normal rat hepatocytes (Hep), rat hepatic stellate cells (HSC), human bile duct epithelial cells (BDEC), normal human (MMNK-1) or mouse (603B) cholangiocyte cell lines, and activated tumor-derived TFK-1 cholangiocytes, normalized to β2MG mRNA (x-fold increase relative to normal human BDEC). Means±SD; *p<0.05 vs. the corresponding control group.

αvβ6 immunostaining of liver sections from sham-operated rats (C), rats with BDL (D) or of normal mouse (603B) (E) and activated human (TFK-1) (F) cholangiocytes. αvβ6 protein is absent from normal livers and 603B cholangiocytes, but highly expressed on proliferating bile duct epithelial cells (red) and TFK-1 cholangiocytes (brown). Shown are representative images (magnification 40×).