Table 2.
Chronic and resolved HCV subjects’ T-cell proliferative responses to recombinant HCV NS3 protein, influenza antigens (H3 and H5) and phytohemagglutinin.
| Antigen | Chronic (n = 8) | Resolved (n = 8) | Significance |
|---|---|---|---|
| NS3† (log ΔCPM) | 3.6 ± 0.2 | 4.2 ± 0.2 | p < 0.05 |
| H3‡ | 3.9 ± 0.2 | 3.9 ± 0.2 | ns |
| H5‡ | 3.3 ± 0.3 | 3.5 ± 0.3 | ns |
| PHA | 4.8 ± 0.3 | 4.9 ± 0.06 | ns |
†
Values are representative of the log mean of three concentrations (0.1, 1 and 10 μg/ml) of recombinant NS3-induced T-cell proliferative response minus background (log ΔCPM). Results are expressed as mean ± standard error of the mean of proliferation. Peripheral blood mononuclear cells were added in triplicate at 1 × 105 cells/well.
‡
Proliferation data are representative of individuals who had a response greater than twofold over medium (control background) for influenza antigens.
CPM: Counts per minute; ns: Not significant; PHA: Phytohemagglutinin.