Table 1.
Sequences of miR-21 and miR-122 and the synthesized antagomirs.a
| miRNA Target/Antagomir | Sequence 5′ → 3′ |
|---|---|
| mature miR-21 | UAGCUUAUCAGACUGAUGUUGA |
| miR-21 antagomir | mA*mU*mC*mA*mA*mC*mA*mU*mC*mA* mG*mU*mC*mU*mG*mA*mU*mA*mA*mG* mC*mU*mA |
| caged miR-21 antagomir | mA*mU*mC*mA*mA*mC*mA*mU*mC*mA* mG*mU*mC*mU*mG*mA*mU*mA*mA*mG* mC*mU*mA |
| mature miR-122 | UGGAGUGUGACAAUGGUGUUUG |
| miR-122 antagomir | mA*mC*mA*mA*mA*mC*mA*mC*mC*mA* mU*mU*mG*mU*mC*mA*mC*mA*mC*mU* mC*mC*mA |
| caged miR-122 antagomir | mA*mC*mA*mA*mA*mC*mA*mC*mC*mA* mU*mU*mG*mU*mC*mA*mC*mA*mC*mU* mC*mC*mA |
a
An asterisk indicates a phosphorothioate bond, an m indicates a 2′OMe modified nucleotide, and a bold mU denotes a NPOM-caged uridine nucleotide.