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. Author manuscript; available in PMC: 2013 Nov 13.
Published in final edited form as: J Chem Theory Comput. 2012 Sep 6;8(11):3998–4003. doi: 10.1021/ct300392f

Fig. 1.

Fig. 1

Exact free-energy profile [Eq. (1)] compared with integrated mean force with and without Jacobian and Leibnizian contributions [Eq. (2)]. All plots are symmetric and anchored at zero value when ξa0 = 0.