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. Author manuscript; available in PMC: 2013 Nov 13.
Published in final edited form as: J Chem Theory Comput. 2012 Sep 6;8(11):3998–4003. doi: 10.1021/ct300392f

Fig. 2.

Fig. 2

Exact free-energy profile [Eq. (1)] compared with integrated orthogonal mean force with and without Jacobian contributions [Eq. (7)], in which the Leibnizian term vanishes. All curves are symmetric and anchored at zero value when ξa0 = 0.