Table 9.
Some alternative meta-analyses for current smoking compared to those in Table8
| Analysis description | Statisticb | All lung cancerc | Squamousd | Adenoe |
|---|---|---|---|---|
| As Table
8a |
n |
195 |
41 |
44 |
| |
F |
9.29 (9.07-9.52) |
13.77 (12.75-14.87) |
4.77 (4.49-5.07) |
| |
R |
8.43 (7.63-9.31) |
16.91 (13.14-21.76) |
4.21 (3.32-5.34) |
| |
H, PH |
13.76, p < 0.001 |
7.22, p < 0.001 |
12.28, p < 0.001 |
| Using more precise outcome definitionf |
n |
187 |
33 |
40 |
| |
F |
9.93 (9.68-10.17) |
12.74 (11.71-13.87) |
4.40 (4.12-4.70) |
| |
R |
8.79 (7.97-9.68) |
16.43 (12.66-21.32) |
4.05 (3.15-5.22) |
| |
H, PH |
11.96, p < 0.001 |
5.70, p < 0.001 |
12.28, p < 0.001 |
| Using least rather than most adjusted estimates |
n |
195 |
41 |
44 |
| |
F |
9.12 (8.91-9.34) |
13.81 (12.79-14.92) |
4.82 (4.53-5.12) |
| |
R |
8.26 (7.49-9.12) |
16.83 (13.12-21.60) |
4.27 (3.37-5.40) |
| |
H, PH |
13.91, p < 0.001 |
7.17, p < 0.001 |
12.33, p < 0.001 |
| Denominator non-smoker rather than never smoker |
n |
188 |
36 |
38 |
| |
F |
3.99 (3.92-4.05) |
3.59 (3.42-3.77) |
2.65 (250–2.80) |
| |
R |
3.75 (3.48-4.03) |
4.71 (3.84-5.79) |
2.46 (2.07-2.93) |
| |
H, PH |
15.67, p < 0.001 |
12.71, p < 0.001 |
7.64, p < 0.001 |
| Preferring results for cigarettes to results for any product |
n |
195 |
41 |
44 |
| |
F |
9.47 (9.25-9.69) |
13.77 (12.75-14.87) |
4.77 (4.49-5.07) |
| |
R |
8.64 (7.83-9.54) |
16.91 (13.14-21.76) |
4.21 (3.32-5.34) |
| |
H, PH |
13.72, p < 0.001 |
7.22, p < 0.001 |
12.28, p < 0.001 |
| Selecting results for cigarettes onlyg |
n |
38 |
8 |
7 |
| |
F |
9.25 (8.81-9.71) |
21.49 (16.73-27.61) |
7.18 (5.71-9.04) |
| |
R |
9.52 (7.89-11.49) |
20.85 (14.84-29.29) |
6.05 (3.69-9.92) |
| |
H, PH |
10.61, p < 0.001 |
1.38, NS |
2.98, p < 0.1 |
| Selecting results specific for age <56 years |
n |
25 |
2 |
3 |
| |
F |
7.64 (6.69-8.73) |
6.48 (2.90-14.52) |
0.74 (0.42-1.32) |
| |
R |
6.57 (4.68-9.23) |
6.48 (2.90-14.52) |
0.74 (0.42-1.32) |
| |
H, PH |
4.17, p < 0.001 |
0.33, NS |
0.21, NS |
| Selecting results specific for age 50–70 years |
n |
24 |
1 |
0 |
| |
F |
10.45 (9.65-11.31) |
26.42 (9.78-71.36) |
|
| |
R |
9.62 (7.10-13.05) |
26.42 (9.78-71.36) |
|
| |
H, PH |
9.99, p < 0.001 |
NA |
|
| Selecting results specific for age 65+ years |
n |
27 |
0 |
0 |
| |
F |
8.79 (8.06-9.58) |
|
|
| |
R |
9.07 (6.83-12.04) |
|
|
| H, PH | 8.37, p < 0.001) |
a See Table 8 for details of the definition of this analysis.
b n = number of estimates combined, F = fixed-effect meta-analysis RR (95% CI), R = random-effects meta-analysis RR (95% CI), H = heterogeneity chisquared per degree of freedom, PH = probability value for heterogeneity expressed as p < 0.001, p < 0.05, p < 0.1 or NS (p ≥ 0.1), PB = probability value for between levels (see Methods) similarly expressed.
c All or nearest available, must include at least squamous cell carcinoma and adenocarcinoma.
d Squamous cell carcinoma or nearest available, but not including adenocarcinoma.
e Adenocarcinoma or nearest available, but not including squamous cell carcinoma.
f Only including results for all lung cancer, squamous cell carcinoma specifically, or adenocarcinoma specifically.
g See also Table 13 (footnote c).