Table 2.
Effects of different treatments on damage score, extension of lesion, changes in colon weight, adherences to adjacent organs and microscopic score
Experimental Groups | Scorea(0–10) | Extension of lesionb(cm) | Colon weightb(mg/cm) | Adherence(%) | Microscopic Score (0-27)a |
---|---|---|---|---|---|
Non-colitic groups |
|
|
|
|
|
Non treated |
0*** |
0** |
112.68 ± 6.28** |
0** |
0** |
20% diet |
0*** |
0** |
113.63 ± 5.56** |
0* |
0** |
Colitic groups |
|
|
|
|
|
TNBS-Control |
7 (4–8) |
3.04 ± 0.33 |
260.63 ± 37.62 |
60 |
10.5 (5–19) |
5% diet |
6 (0–7) |
1.67 ± 0.42* |
156.67 ± 16.76* |
15* |
8 (5–15) |
10% diet |
5 (4–6) |
1.45 ± 0.29* |
169.24 ± 6.12* |
0* |
5 (3–11) |
20% diet |
6 (4–8) |
2.17 ± 0.36 |
204.75 ± 22.81 |
85 |
4 (2–10) |
5% diet + prednisolone |
7 (5–10) |
3.24 ± 0.59 |
196.73 ± 23.22 |
15* |
5 (2–14) |
10% diet + prednisolone |
6 (5–7) |
2.43 ± .029 |
156.01 ± 9.87* |
45 |
7 (2–11) |
20% diet + prednisolone |
6 (0–8) |
2.41 ± 0.68 |
258.04 ± 63.77 |
45 |
5 (1–9) |
prednisolone | 3 (0–4)* | 1.40 ± 0.27* | 162.20 ± 8.14* | 45 | 11.0 (8–14) |
a Score and microscopic score data are expressed as median (range) and were statically evaluated by non-parametric Kruskal-Wallis test; b Extension of lesion and colonic weight data are expressed as mean ± SEM values and differences were assessed using ANOVA was followed by post hoc test of Dunnet; Adherence was expressed in percentage and was analyzed with the χ2 test. *P < 0.05, P < 0.01 and P < 0.001 versus TNBS control group.