Table 1.
Classification of detoxification gene families in Drosophila melanogaster, Anopheles gambiae, Aedes aegypti, and Culex pipiens quinquefasciatus
| D. melanogaster | A. gambiae | A. aegypti | C. p. quinquefasciatus | |
|---|---|---|---|---|
| CCE |
|
|
|
|
| Dietary/detoxification* |
|
|
|
|
| B class (α-esterases) |
13 |
16 |
22 |
30 (18) |
| Hormone/semiochemical processing |
|
|
|
|
| D class (integument esterases) |
3 |
0 |
0 |
1 (0) |
| E class (β-esterases) |
2 |
4 |
2 |
3 (3) |
| F class (dipteran JH esterases) |
3 |
6 |
7 |
13 (5) |
| G class (lepidopteran JH esterases) |
0 |
4 |
6 |
9 (6) |
| Neuro/developmental |
|
|
|
|
| H class (glutactins) |
5 |
10 |
7 |
6 (5) |
| I class (unknown) |
1 |
1 |
1 |
1 (1) |
| J class (acetylcholinesterases) |
1 |
2 |
2 |
2 (2) |
| K class (gliotactins) |
1 |
1 |
1 |
1 (1) |
| L class (neuroligins) |
4 |
5 |
5 |
3 (3) |
| M class (neurotactins) |
2 |
2 |
2 |
2 (2) |
| Total |
35 |
51 |
55 |
71 (46) |
| P450 |
|
|
|
|
| CYP2 |
6 |
10 |
11 |
14 (12) |
| CYP3 (include CYP6 and CYP9) |
36 |
42 |
84 |
88 (72) |
| CYP4 |
32 |
45 |
59 |
83 (58) |
| Mitochondrial |
11 |
9 |
10 |
11 (8) |
| Total |
85 |
106 |
164 |
196 (150) |
| GST |
|
|
|
|
| Delta |
11 |
12 |
8 |
14 (13) |
| Epsilon |
14 |
8 |
8 |
10 (6) |
| Omega |
5 |
1 |
1 |
1 (1) |
| Sigma |
1 |
1 |
1 |
1 (1) |
| Theta |
4 |
2 |
4 |
6 (6) |
| Zeta |
2 |
1 |
1 |
0 (0) |
| Others |
0 |
3 |
3 |
3 (2) |
| Total | 37 | 28 | 26 | 35 (29) |
*The dietary/detoxification functional group follows the new system proposed by Oakeshott et al. (2010).
Data of D. melanogaster, An. gambiae, and Ae. aegypti are taken from Oakeshott et al. (2010).
The number of C. p. quinquefasciatus genes in brackets is from the DGE libraries.
CCE, carboxyl/cholinesterases; P450, cytochrome P450 monooxygenases; GST, glutathione S-transferases.