Figure 3.

Hypermethylation in the KCNA3 promoter region across multiple cancer types. Voltage gated channel activity is highly enriched with hypermethylated genes. The silencing of potassium voltage-gated channel, shaker-related subfamily, member 3 (KCNA3) via promoter methylation has been reported in breast and pancreas tumors. Here, we observe KCNA3 promoter methylation as a prevalent event across multiple cancer types including lung, ovarian, kidney, prostate, and colon. FDR levels were calculated using LIMMA package as described in methods.