Table 3.

Ongoing phase III clinical trials targeting pancreatic cancer stroma related molecules^*

Stromal targets	Agent in treatment	Disease stage
VEGF receptor and other tyrosine kinases	Gemcitabine, sorafenib	Advanced or metastatic pancreatic cancer
EGFR	Gemcitabine, erlotinib, radiation, capecitabine, fluorouracil	Patients with pancreatic cancer that has been removed by surgery
VEGF receptor and other tyrosine kinases	Axitinib and gemcitabine	Advanced pancreatic cancer
EGFR	Erlotinib, capecitabine and gemcitabine	Locally advanced or metastatic
VEGF	Aflibercept and gemcitabine	Locally advanced or metastatic
SPARC	Nab-Paclitaxel, gemcitabine	Advanced pancreatic cancer

^*base on The National Cancer Institute website)