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. Author manuscript; available in PMC: 2013 May 1.
Published in final edited form as: Expert Rev Clin Immunol. 2012 Jul;8(5):427–438. doi: 10.1586/eci.12.34

Table 1.

Clinical myasthenia gravis subtypes and associated autoantibodies.

MG subtype Age at onset Thymic histology Muscle autoantibodies
Early onset <50 years Hyperplasia

  • AChRs
Late onset >50 years Normal

  • AChRs

  • Titin

  • Ryanodine

  • VGKC (Kv1.4)
Thymomatous Any age; peak at 40–60 years Neoplasia

  • AChR

  • Titin

  • Ryanodine

  • VGKC (Kv1.4)
MuSK – Minimal

  • MuSK
Ocular Variable Unknown

  • AChRs (50%)

  • ? Low-affinity AChRs
Double-seronegative Variable Unknown

  • Low-affinity AChRs

  • LRP4 antibodies

  • ? Others

AChR: Acetylcholine receptor; LRP4: Lipoprotein-related protein receptor 4; MG: Myasthenia gravis; MuSK: Muscle-specific tyrosine kinase; VGKC: Voltage-gated potassium channel.