Table 2.
Overview of behavioural parameters measured in the modified hole board
| Behavioural Category | BALB/c | 129P2 | ||||||
|---|---|---|---|---|---|---|---|---|
| Behavioural Parameter | ANOVA Effects@ | Trial 1 | Trial 36 | Trial 37 (First Reversal) | Trial 1 | Trial 36 | Trial 37 (First Reversal) | |
| Cognition | Latency end task | T, S | 300.0 ± 0.0 | 38.3 ± 6.6 | 90.0 ± 6.8 | 296.8 ± 3.2 | 68.5 ± 8.2 | 119.5 ± 23.1 |
| Latency first visit baited hole | T, S, T × S | 238.2 ± 28.7 | 11.7 ± 4.5 | 29.1 ± 3.1 | 282.2 ± 12.0 | 16.1 ± 3.1 | 37.3 ± 10.9 | |
| Omission errors | T, S, T × S | 3 (0) | 0 (0) | 0 (0) | 3 (0.5) | 0 (0) | 0 (0) | |
| Revisit baited hole | T, S, T × S | 0 (0) | 0 (0.5) | 0 (0.5) | 0 (0) | 0 (1) | 1 (0) | |
| Visit nonbaited hole | T, S, T × S | 2 (1.5) | 0 (0) | 3 (4) | 1 (0.5) | 0 (0) | 3 (2) | |
| Wrong choice | T, S, T × S | 2 (2) | 0 (0.5) | 3 (2) | 1 (0.5) | 0 (1) | 4 (2) | |
| Avoidance | Latency board | T, T × S | 31.8 ± 5.4 | 4.1 ± 4.0 | 6.5 ± 1.6 | 17.4 ± 1.7 | 12.4 ± 3.0 | 11.5 ± 1.9 |
| Time spent on board | T, T × S | 81.9 ± 4.3 | 66.6 ± 5.6 | 55.2 ± 3.2 | 92.9 ± 0.8 | 55.9 ± 6.5 | 53.0 ± 5.4 | |
| Board entries | T, S | 5 (4.0) | 3.5 (2.5) | 10 (3) | 2 (1.5) | 2 (1) | 5 (3) | |
| Risk assessment | Stretched attends | T, T × S | 42 (18) | 0 (0) | 0 (0) | 27 (4.5) | 0 (0) | 0 (0) |
| Latency stretched attend | T, S, T × S | 3.6 ± 0.5 | 300.0 ± 0.0 | 300.0 ± 0.0 | 4.4 ± 0.9 | 300.0 ± 0.0 | 300.0 ± 0.0 | |
| Locomotion | Line crossings | T, S, T × S | 2 (5) | 12 (4.5) | 28 (14) | 2 (0.5) | 5 (7.5) | 13 (13) |
| Latency line crossing | T, S | 13.4 ± 4.4 | 1.5 ± 0.2 | 1.5 ± 0.1 | 98.2 ± 43.2 | 4.5 ± 1.3 | 1.8 ± 0.3 | |
| Time spent immobile | S | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.37 ± 0.37 | 0.0 ± 0.0 | 0.0 ± 0.0 | |
| Latency immobility | T, S | 300.0 ± 0.0 | 300.0 ± 0.0 | 300.0 ± 0.0 | 283.3 ± 16.7 | 300.0 ± 0.0 | 300.0 ± 0.0 | |
| Exploration | Rearings box | T, S | 0 (1) | 0 (1.5) | 2 (2) | 0 (0) | 0(0) | 1 (3) |
| Rearings board | T | 0 (1) | 0 (0) | 0 (0) | 0 (0.5) | 0 (0) | 0 (0) | |
| Hole explorations | T, S, T × S | 20 (18) | 2 (4) | 7 (3) | 16 (12.5) | 2 (2) | 4 (4) | |
| Arousal | Time spent grooming | S | 0.48 ± 0.1 | 0.3 ± 0.3 | 0.5 ± 0.2 | 0.3 ± 0.2 | 0.2 ± 0.2 | 0.0 ± 0.0 |
| Latency grooming | S | 255.3 ± 15.6 | 274.4 ± 25.6 | 230.5 ± 35.9 | 285.0 ± 10.0 | 279.6 ± 20.4 | 300.0 ± 0.0 | |
| Defecations | T | 4 (6) | 0 (0) | 0 (0) | 3 (4) | 0 (0) | 0 (1) |
Data for the 1st trial, the 36th trial, and the first reversal trial are shown as means ± SEMs for continuous data; ordinal data are shown as medians with an interquartile range in parentheses. @ANOVA effects significant at p < .05: T = trial effect; S = strain effect; T × S = Trial × Strain interaction effect.