Table 1.
Blood and muscle measures
| Baseline | Week 11 | |
|---|---|---|
| Blood measures | ||
| Total testosterone (ng/dl) | 16 | 1,210 |
| Free testosterone (pg/ml) | 0.4 | 28 |
| Estradiol (pg/ml) | <25 | 43 |
| FSH (mIU/ml) | 8.33 | 0.118 |
| LH (mIU/ml) | 0.429 | 0.280 |
| PRL (ng/ml) | 5.44 | 17.1 |
| SHBG (nmol/l) | Not determined | 71 |
| IGF-1 (ng/ml) | 153 | 69 |
| Cholesterol (mg/dl) | 186 | 118 |
| Triglycerides (mg/dl) | 277 | 144 |
| HDL cholesterol (mg/dl) | 36 | 15 |
| LDL cholesterol (mg/dl) | 105 | 74 |
| Cortisol (μg/dl) | 11.6 | 5.97 |
| TNF-α (pg/ml) | 15.9 | 12.2 |
| IL-6 (pg/ml) | 13.6 | 21.9 |
| IL-7 (pg/ml) | 5.6 | 6.2 |
| IL-8 (pg/ml) | 19.8 | 26.7 |
| IL-10 (pg/m) | 5.8 | 2.0 |
| Skeletal muscle measures | ||
| Skeletal muscle protein kinetics | ||
| Fasting FSR (% h−1) | 0.07 | 0.06 |
| Fasting FBR (% h−1) | 0.03 | 0.09 |
| Cell signaling (cytosol) | ||
| Akt (arbitrary units) | 0.44 | 2.02 |
| AMPKα (arbitrary units) | 1.22 | 0.89 |
| Phospho-FoxO1 (arbitrary units) | 1.36 | 1.42 |
| Phospho-FoxO3 (arbitrary units) | 0.95 | 0.87 |
| GSK (arbitrary units) | 0.74 | 0.72 |
| Smad2 (arbitrary units) | 0.77 | 0.85 |
| Smad3 (arbitrary units) | 1.04 | 2.71 |