FIG. 3.

Quinoline derivatives protect against short-term (400 μM × 1 h) and long-term (50 μM × 6 h) gentamicin damage protocols. Previous studies (Owens et al. 2009) suggest that different death pathways are involved in short- and long-term gentamicin damage in the zebrafish lateral line. A Pretreatment with each of the eight quinoline derivatives provided significant protection against short-term gentamicin-induced hair cell death (**F(8, 88) = 21.88, p < 0.0001, one-way ANOVA). Similarly, in B, each of the eight quinoline derivatives protected against long-term gentamicin-induced hair cell death (**F(8, 75) = 25.47, p < 0.0001, one-way ANOVA). Data bars represent the mean hair cell survival of eight to ten fish. Error bars = ±1 SD from the mean.