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. 2012 Jul 24;13(6):745–758. doi: 10.1007/s10162-012-0342-3

FIG. 3.

FIG. 3

Pharmacological characterization of I h. A Inward current was blocked by extracellular application of 1 mM CsCl. Currents shown for voltage steps from −79 to −149 mV. B Block of I h by ZD7288 was concentration dependent. I end − I ins was reduced by 20 % in the presence of 50 μM ZD7288 and by 91 % in 100 μM ZD7288. Currents shown in response to a voltage step from −79 to −144 mV. The fast inward deflections seen on these and other records are likely excitatory postsynaptic currents (EPSCs) as described previously (Rennie and Streeter 2006; Yi et al. 2010). C Mean percent decrease in I end − I ins amplitude was 97.3 % in the presence of 1–5 mM Cs+ (n = 9) and 83.3 % in 100 μM ZD7288 (n = 8). D Mean outward potassium currents are unchanged after application of ZD7288 (n = 3). Current amplitude was measured at the end of 40 ms voltage steps.