TABLE 1.

Pharmacokinetic parameters derived by simulation

Substance	n	Injection Time (min)	Delay Time (min)	ST elimination half-time (min)	SV/ SM elimination Half-time (min)	SCC elimination half-time (min)	CSF influx rate (nl/min)
TMPA	5	30	120	29	172	170	0.058
TMPA	3	60	120	40	620	64	0.025
TMPA	3	90	120	38.9	188	256	0.059
TMPA	5	30	30	14	250	100	0.060
TMPA	3	30	60	13	2200	85	0.075
TMPA	3	30	180	36.4	241	102	0.100
TMPA	1	30	240	39.5	175	135	0.055
Average TMPA				24.5	259	109	0.062
Fluorescein	3	60	60	55	None	600	0.070
Fluorescein	4	60	120	58	3800	250	0.060
Fluorescein	3	60	240	50	680	262	0.095
Average Fluorescein				54.1	1730	316	0.075
mDex	3	60	60	33.2	90	89	0.010
mDex	3	60	120	18.8	125	55	0
mDex	3	60	240	20.0	126	130	0
Average mDex				22.5	110.9	80.8	0.003
Dex P	1	30	120	16	1250	1000	0.09
Dex-P	1	30	180	20	212	170	0.14
Dex-P	1	30	180	19.5	209	167	0.06
Average DexP				18.3	291.2	233	0.097

This analysis shows that elimination rates are different in ST and SV. As half-times are typically not normally distributed, the average half-time shown is calculated as log_e(2)/k, where k is the average of the individually-calculated rate constants, each calculated as log_e(2)/half-time