Figure 1.

Receiver operating characteristic (ROC) curves for the multivariable prediction model (A) versus PSA alone (B) for predicting histologically-aggressive prostate cancer in the EDRN analysis cohort (n=635), and for the model-predicted risks in the PCPT validation cohort (C; n=3833). In the EDRN cohort, for a sensitivity of 90%, specificity was 42% versus 32% for PSA; for a sensitivity 80%, specificity was 60% versus 48% for PSA (denoted by closed circles).
Abbreviations: PSA=prostate specific antigen; AUC=area under the ROC curve.