Table 2.
Multivariable model of demographic and pre-biopsy clinical characteristics for the presence of histologically-aggressive prostate cancer on first prostate biopsy in the EDRN analysis cohort.
| Parameter | Estimate | Standard Error |
Odds Ratio (95% CI) |
P-value |
|---|---|---|---|---|
| Intercept | −3.28 | 1.04 | - | - |
| Age (per 10 yrs) | 0.54 | 0.12 | 1.72 (1.35, 2.18) | <0.0001 |
| BMI (per 1 kg/m2) | 0.06 | 0.02 | 1.07 (1.02, 1.11) | 0.002 |
| Family history of prostate cancer |
0.82 | 0.23 | 2.27 (1.45, 3.54) | 0.0003 |
| Abnormal DRE | 1.08 | 0.25 | 2.95 (1.81, 4.80) | <0.0001 |
| Log PSA density (per 1 unit) | 1.51 | 0.17 | 4.51 (3.25, 6.27) | <0.0001 |
Abbreviations: BMI=body mass index; PSA=prostate specific antigen; DRE=digital rectal exam; CI=confidence interval