TABLE 1.

Nomenclature of targeted alleles^a

Allele nomenclature	Selectable marker	Gene targeting strategy
Lmo1−	Neomycin	neo insertion
Lmo1Z	Neomycin	IRES-lacZ insertion
Lmo3−	Neomycin	neo insertion
Lmo3Z	Neomycin	IRES-lacZ insertion
Lmo4−	Neomycin	neo insertion
Lmo4-GFP	Hygromycin	GFP knockin

^aThe various Lmo gene targeted alleles used in the study comprise either (i) gene inactivation by insertion of a gene encoding a selectable marker (either neomycin [neo] or hygromycin [hyg] genes) to create the Lmo⁻ allele, (ii) inactivation using insertion of an IRES-lacZ cassette including a neo gene to create the LmoZ allele, or (iii) knockin of the GFP gene in frame with the Lmo4 coding sequence (together with the hyg selectable marker) to create the Lmo4-GFP allele. Compound Lmo1 and Lmo3 genotypes comprising combinations of alleles are designated +/− (a wild-type and a neo insertion allele), Z/+ (IRES-lacZ insertion and a wild-type allele), and Z/Z (both alleles have IRES-lacZ insertions).