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Summary of effects of null mutation of the Lmo family genes
| Targeted gene(s) | Effect of null mutation on viability | Tissue affected | Other defects |
|---|---|---|---|
| Lmo1 | None | None detectable | |
| Lmo2 | Death at E9.5 | Failure of primitive erythropoiesis | Failure of adult hematopoiesis, failure of angiogenesis (assessed in chimeras) |
| Lmo3 | None | None detectable | |
| Lmo1 + Lmo3 | Immediate postnatal death | Unspecified central nervous system abnormalities | |
| Lmo4 | Perinatal death | Neural tube closure defect |
