Table 1.
Comparison of physiological indices in different experimental groups.
| Groups | BW gain (g) | Obesity index | LN insulin (m IU/mL) |
HOMA-ISI | 24 h UAE (μg/100 g BW) |
|---|---|---|---|---|---|
| Control | 246.7 ± 30.6 | 315.9 ± 15.8 | 3.54 ± 0.26 | 0.054 ± 0.009 | 2.45 ± 0.53 |
| Model | 353.4 ± 29.4† | 347.0 ± 7.3† | 4.38 ± 0.18† | 0.039 ± 0.005† | 6.14 ± 0.89† |
| Losartan (L) | 360.2 ± 62.8† | 347.2 ± 9.4† | 4.44 ± 0.17†# | 0.037 ± 0.007†# | 4.45 ± 0.85∗†# |
| Pioglitazone (P) | 368.8 ± 30.7† | 342.9 ± 13.1† | 3.88 ± 0.33* | 0.051 ± 0.006* | 4.20 ± 0.70∗†# |
| Combination (L + P) | 365.3 ± 46.5† | 345.8 ± 17.7† | 4.05 ± 0.20†∗ | 0.051 ± 0.011* | 3.35 ± 0.55∗† |
Values are expressed as mean ± SD, n = 6-7 per group. *P < 0.05 versus model group. † P < 0.05 versus control group. # P < 0.05 versus L + P group. Body weight (BW) gain was calculated by subtracting the initial weight from the final weight. Obesity index was calculated as the cubic root of BW (g) divided by body length (cm) × 103. LN insulin: natural logarithm-transformed insulin; HOMA-ISI: homeostasis model assessment insulin sensitivity index.