FIG. 9.

Proposed model for cooperative linking of p160 and SWI/SNF coactivator complexes by Fli-I protein. Fli-I protein can bind to components of the p160 coactivator complex (p160 and CARM1), which contains histone acetylating (CBP/p300) and methylating (CARM1) activities. Fli-I can also bind to actin and the actin-like protein BAF53, both of which are components of the ATP-dependent nucleosome-remodeling complex SWI/SNF. Thus, one possible mechanism for the contribution of Fli-I as a coactivator could be to facilitate the recruitment of or somehow coordinate the complementary chromatin-remodeling activities of the SWI/SNF complex and the p160 coactivator complex. H, hormone.