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. Author manuscript; available in PMC: 2012 Nov 25.
Published in final edited form as: Am J Surg Pathol. 2011 Oct;35(10):1549–1556. doi: 10.1097/PAS.0b013e31822895e5

Figure 4.

Figure 4

Diagrammatic representation of the mTOR and hypoxia-induced pathways. In tumors with activation of the mTOR pathway the use of mTOR inhibitors, such as sirolimus (Rapamycin) and derived drugs, may be beneficial. Blunt-ended arrows indicate inhibitory effects in the targeted molecule.