TABLE 4.
Univariate Analysis Model including Clinicopathologic Parameters and Biomarker Expression Levels as Prognosticators of Outcome in Primary ccRCC
| Clinicopathologic parameters | Outcome | ||||
|---|---|---|---|---|---|
| pT | Fuhrman | Size | DSS | Progression | |
| pT | N/A | N/A | N/A | 0.0008 | 0.0001 |
| Fuhrman | N/A | N/A | N/A | NS | NS |
| Gender | N/A | N/A | N/A | NS | NS |
| Size | N/A | N/A | N/A | 0.0001 | 0.0001 |
|
| |||||
| Biomarkers expression | |||||
|
| |||||
| PTEN | 0.032 | NS | NS | NS | NS |
| phos-AKT | 0.004 | NS | NS | NS | NS |
| phos-S6 | 0.0004 | NS | NS | 0.0001 | 0.0001 |
| 4EBP1 | 0.036 | NS | 0.025 | 0.0152 | 0.0025 |
| c-MYC | 0.008 | NS | NS | NS | NS |
| p27 | 0.0001 | 0.031 | 0.0001 | 0.031 | 0.0093 |
| HIF-1α | 0.016 | NS | 0.009 | 0.0009 | 0.0007 |
ccRCC: clear cell renal cell carcinoma; DSS: Disease-Specific Survival; N/A: not applicable; NS: nonsignificant (P>0.05)