Table 2.
Genes showing differential expression in TG-NS hearts by microarray analysis
| A. Genes involved in interferon (IFN)-signaling pathways | ||||
| Accession # | Symbol | Gene | P value |
Fold of
change |
|
| ||||
| NM_008332.1 | Ifit 2 | Interferon-induced protein with tetratricopeptide repeats 2 |
1.3 × 10−4 | 43.9 |
| NM_011909.1 | Usp18 | Ubiquitin specific protease 18 | 6.5 × 10−5 | 31.8 |
| NM_010501.1 | Ifit 3 | Interferon-induced protein with tetratricopeptide repeats 3 |
8.3 × 10−4 | 31.5 |
| NM_008331.1 | Ifit 1 | Interferon-induced protein with tetratricopeptide repeats 1 |
2.2 × 10−4 | 26.0 |
| NM_016850.1 | Irf 7 | Interferon regulatory factor 7 | 1.3 × 10−4 | 18.6 |
| NM_018734.1 | Gbp3 | Guanylate nucleotide binding protein 3 | 1.8 × 10−4 | 13.5 |
| AF136520 | Dlm-1 | Tumor stroma and activated macrophage protein DLM-1 |
8.6 × 10−6 | 12.9 |
| NM_009283 | STAT1 * | Signal transducer and activator of transcription 1 |
4.0 × 10−6 | 9.8 |
| AB067533.1 | Oasl 9 | 2,5-Oligoadenylate synthetase-like 9 | 9.8 × 10−4 | 6.6 |
| BC018470 | Oasl 1G | 2′-5′ Oligoadenylate synthetase 1G | 2.0 × 10−4 | 6.5 |
| AY090098.1 | Isg 12 | Interferon stimulated gene 12 | 2.7 × 10−4 | 6.2 |
|
| ||||
| B. Genes with a potential role in apoptosis and inflammation | ||||
| Accession # | Symbol | Gene | P value |
Fold of
change |
|
| ||||
| NM_009283 | STAT1 * | Signal transducer and activator of transcription 1 |
4.0 × 10−6 | 9.8 |
|
| ||||
| AY075132 | Helicard | Helicard | 2.1 × 10−5 | 7.9 |
| AF220142 |
Trim34
delta |
Tripartite motif protein 34 delta | 8.1 × 10−5 | 5.5 |
| NM_126166 | Tlr3 | Toll-like receptor 3 | 2.5 × 10−4 | 5.4 |
*
STAT1 is involved in both IFN signaling and apoptosis.