Table 1.
Incubation period (IP) data in wild‐type mice.
| Case ID | Brain area | Mouse line | Np/N | Nc | Incubation period (days) | |
|---|---|---|---|---|---|---|
| Mean (SD) | C57BL—RIII | |||||
| UK‐1 | Occipital cortex | RIII | 7/20 | 4 | 505 (18.1) | 162 |
| C57BL | 8/20 | 5 | 667 (46.1) | |||
| VM | 3/20 | 0 | — | |||
| UK‐2 | Obex | RIII | 7/15 | 3 | 476 (27.4) | 205 |
| C57BL | 10/15 | 6 | 680 (25.3) | |||
| VM | 9/15 | 3 | 697 (25.1) | |||
| Ovine BSE 1 | Obex | RIII | 18/20 | 14 | 388 (41.1) | 116 |
| C57BL | 16/20 | 10 | 504 (112.3) | |||
| VM | 13/20 | 0 | — | |||
| Ovine BSE 2 | Obex | RIII | 11/20 | 11 | 342 (10.8) | |
| Bovine BSE | Obex | RIII | 8/20 | 8 | 431 (38.6) | |
Np indicates the number of transmissible spongiform encephalopathy (TSE)‐positive mice irrespective of their clinical status. N indicates the total number of inoculated mice. Nc indicates the subset of Np mice that also showed clinical signs of TSE; only Nc mice were used in the calculation of incubation period data. C57BL—RIII denotes the incubation period (IP) difference between C57BL and RIII for each case. SD indicates standard deviation. BSE, bovine spongiform encephalopathy.