Table 2.
Attack rates and incubations periods of UK‐1 and UK‐2 following transmission to ovine transgenic mice.
| Case ID | Mouse Line | VLA | INRA | FLI | |||
|---|---|---|---|---|---|---|---|
| Nc/N | IP (SD) | Nc/N | IP (SD) | Nc/N | IP (SD) | ||
| UK‐1 | tg338 (all) | 16/20 | 121 (21.9) | 12/12 | 141 (26.2) | ||
| tg338 (P338)* | 3/20 | 158 (5.1) | 6/12 | 161 (10.0) | |||
| tg333 (G338)* | 10/20 | 107 (8.1) | 5/12 | 113 (12.2) | |||
| tg338 (Composite)* | 3/20 | 130 (1.7) | 1/12 | 155 | |||
| TgshpXI | 20/20 | 184 (29.2) | 15/15 | 166 (19.4) | |||
| UK‐2 | tg338 | 20/20 | 149 (3.1) | 12/12 | 143 (5.4) | ||
| TgshpXI | 17/20 | 164 (7.3) | 14/15 | 196 (67.3) | |||
| Classical scrapie | tg338 | 10/10 | 154 (3.3) | ||||
See Figure 8.
Attack rates and mean incubation period (IP) data for transmissions of UK‐1 and UK‐2 to tg338 and TgshpXI mice carried out at Veterinary Laboratories Agency (VLA), French National Institute for Agricultural Research (INRA) and Friedrich‐Loeffler‐Institut (FLI) are shown. Classical scrapie data following transmission to tg338 mice is included for comparison. In the case of UK‐1, mean IP correlating to the distinct PrPSc immunohistochemical (IHC) deposition patterns shown by individual mice are also reported (P338, G338 and composite). Nc indicates the number of mice diagnosed as transmissible spongiform encephalopathy (TSE)‐positive that also exhibited clinical signs of TSE; N indicates the number of mice inoculated. SD indicates standard deviation.