Table 6.
Influence of PN macronutrient dose on infection in HPN patients
| Factor | BSI | Non-BSI | Total Infections | ||||||
|---|---|---|---|---|---|---|---|---|---|
| IRR | 95% CI | P Value | IRR | 95% CI | P Value | IRR | 95% CI | P Value | |
| Dextrose (gm/kg BW) | |||||||||
| ≥3.83 | 1.47 | 0.81–2.65 | 0.20 | 4.52 | 1.49–3.80 | 0.0078 | 2.10 | 1.11–4.00 | 0.023 |
| 2.79–3.82 | 1.35 | 0.72–2.53 | 0.36 | 3.48 | 1.24–9.75 | 0.018 | 1.82 | 0.94–3.53 | 0.08 |
| 2.17–2.78 | 1.90 | 0.98–3.66 | 0.06 | 5.95 | 2.15–16.46 | 0.0006 | 2.85 | 1.51–5.37 | 0.0012 |
| < 2.17 | 1.00 | -- | -- | 1.00 | -- | -- | 1.00 | -- | -- |
| Lipids (gm/kg BW) | |||||||||
| ≥0.99 | 0.89 | 0.52–1.53 | 0.68 | 2.99 | 1.19–7.53 | 0.02 | 1.47 | 0.83–2.60 | 0.19 |
| 0.76–0.98 | 0.99 | 0.50–1.96 | 0.97 | 0.99 | 0.33–2.97 | 0.98 | 1.01 | 0.52–1.97 | 0.97 |
| 0.54–0.75 | 0.81 | 0.47–1.38 | 0.43 | 1.94 | 0.71–5.29 | 0.20 | 1.13 | 0.63–2.04 | 0.68 |
| < 0.54 | 1.00 | -- | -- | 1.00 | -- | -- | 1.00 | -- | -- |
| Calories (kcal/kg BW) | |||||||||
| ≥ 29.1 | 0.85 | 0.48–1.52 | 0.58 | 3.51 | 1.44–8.55 | 0.0058 | 1.42 | 0.26–2.65 | 0.28 |
| 23.0–29.0 | 0.96 | 0.56–1.66 | 0.89 | 1.72 | 0.65–4.59 | 0.28 | 1.14 | 0.63–2.06 | 0.66 |
| 17.8–22.9 | 1.06 | 0.56–2.01 | 0.86 | 3.54 | 1.43–8.75 | 0.006 | 1.66 | 0.90–3.06 | 0.10 |
| < 17.8 | 1.00 | -- | -- | 1.00 | -- | -- | 1.00 | -- | -- |
BW, body weight; CI, Confidence interval; HPN, home parenteral nutrition; ICU, intensive care unit. Infections are those that occurred during period of observation within the first 6 months after hospital discharge. Doses of parenteral dextrose, lipid emulsion, and total calories, respectively, are the average macronutrient dose/day during the period of observation within the first 6 months after hospital discharge.