Skip to main content
PMC home page
Infection and Immunity logoLink to Infection and Immunity
. 1981 Apr;32(1):28–31. doi: 10.1128/iai.32.1.28-31.1981

High interferon titer in newborn pig intestine during experimentally induced viral enteritis.

C La Bonnardiere, H Laude
PMCID: PMC350581  PMID: 6163724

Abstract

We looked for the presence of interferon in the digestive tract of newborn piglets infected with a virulent strain of transmissible gastroenteritis virus (Coronaviridae). High levels of type 1 interferon activity were found early in the disease in jejunal and ileal parts of the intestine as well as in the serum. Enterocytes appeared to be involved in the interferon synthesis. These findings raise the question of the role of interferon in the pathogenesis of viral enteritis.

Full text

PDF
28

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aelterman E. O., Hooper B. E. Transmissible gastroenteritis of swine as a model for the study of enteric disease. Gastroenterology. 1967 Jul;53(1):109–113. [PubMed] [Google Scholar]
  2. Albright D. J., Whalen R. A., Blacklow N. R. Sensitivity of human foetal intestine to interferon. Nature. 1974 Jan 25;247(5438):218–220. doi: 10.1038/247218a0. [DOI] [PubMed] [Google Scholar]
  3. Carter W. A., Davis L. R., Jr, Chadha K. C., Johnson F. H., Jr Porcine leukocyte interferon and antiviral activity in human cells. Mol Pharmacol. 1979 May;15(3):685–690. [PubMed] [Google Scholar]
  4. Dolin R., Baron S. Absence of detectable interferon in jejunal biopsies, jejunal aspirates, and sera in experimentally induced viral gastroenteritis in man. Proc Soc Exp Biol Med. 1975 Nov;150(2):337–339. doi: 10.3181/00379727-150-39031. [DOI] [PubMed] [Google Scholar]
  5. Frederick G. T., Bohl E. H. Local and systemic cell-mediated immunity against transmissible gastroenteritis, an intestinal viral infection of swine. J Immunol. 1976 Apr;116(4):1000–1004. [PubMed] [Google Scholar]
  6. Gresser I., Tovey M. G., Maury C., Chouroulinkov I. Lethality of interferon preparations for newborn mice. Nature. 1975 Nov 6;258(5530):76–78. doi: 10.1038/258076a0. [DOI] [PubMed] [Google Scholar]
  7. Gresser J., Morel-Maroger L., Verroust P., Rivière Y., Guillon J. C. Anti-interferon globulin inhibits the development of glomerulonephritis in mice infected at birth with lymphocytic choriomeningitis virus. Proc Natl Acad Sci U S A. 1978 Jul;75(7):3413–3416. doi: 10.1073/pnas.75.7.3413. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Hamilton J. R., Gall D. G., Kerzner B., Butler D. G., Middleton P. J. Recent developments in viral gastroenteritis. Pediatr Clin North Am. 1975 Nov;22(4):747–755. doi: 10.1016/S0031-3955(16)33205-9. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Holmes I. H. Viral gastroenteritis. Prog Med Virol. 1979;25:1–36. [PubMed] [Google Scholar]
  10. Kodama Y., Ogata M., Simizu Y. Characterization of immunoglobulin A antibody in serum of swine inoculated with transmissible gastroenteritis virus. Am J Vet Res. 1980 May;41(5):740–745. [PubMed] [Google Scholar]
  11. Laude H. Virus de la peste porcine classique : isolement d'une souche cytolytique a partir de cellules IB-RS2. Ann Microbiol (Paris) 1978 May-Jun;129(4):553–561. [PubMed] [Google Scholar]
  12. Mebus C. A., Torres-Medina A., Twiehaus M. J., Bass E. P. Immune response to orally administered calf reovirus-like agent and coronavirus vaccine. Dev Biol Stand. 1976;33:396–403. [PubMed] [Google Scholar]
  13. Pensaert M., Haelterman E. O., Burnstein T. Transmissible gastroenteritis of swine: virus-intestinal cell interactions. I. Immunofluorescence, histopathology and virus production in the small intestine through the course of infection. Arch Gesamte Virusforsch. 1970;31(3):321–334. doi: 10.1007/BF01253767. [DOI] [PubMed] [Google Scholar]
  14. Shimizu M., Shimizu Y. Lymphocyte proliferative response to viral antigen in pigs infected with transmissible gastroenteritis virus. Infect Immun. 1979 Feb;23(2):239–243. doi: 10.1128/iai.23.2.239-243.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Torlone V., Titoli F., Gialletti L. Circulating interferon production in pigs infected with hog cholera virus. Life Sci. 1965 Sep;4(17):1707–1713. doi: 10.1016/0024-3205(65)90218-3. [DOI] [PubMed] [Google Scholar]
  16. Weiser M. M. Intestinal epithelial cell surface membrane glycoprotein synthesis. I. An indicator of cellular differentiation. J Biol Chem. 1973 Apr 10;248(7):2536–2541. [PubMed] [Google Scholar]
  17. Welliver R. C., Ogra P. L. Importance of local immunity in enteric infection. J Am Vet Med Assoc. 1978 Sep 1;173(5 Pt 2):560–564. [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES