Figure 7.
Comparison of binding under static vs dynamic conditions for varying peptide molar concentrations for NGR and VHP-conjugated liposomes. A) NGR-conjugated liposome binding under static and dynamic (4.4 dyne/cm2 shear stress with the USC) conditions. Particle binding increased with peptide concentration (p < 0.01 except from 4 to 6%), but consistently decreased under shear (p < 0.01 except for 1%) (N ≥ 3). B) VHP-conjugated liposome binding under static and shear conditions. Particle binding consistently increased with peptide concentration (p < 0.01), and also increased under shear (p < 0.01 except for 1%, up to 13-fold) (N ≥ 3). C) Binding of NGR and VHP-conjugated liposome in side by side comparison.