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. 2012 Nov 15;26(22):2499–2511. doi: 10.1101/gad.200329.112

Figure 4.

Figure 4.

Inhibition of H3K9me2 patterning in HSPCs results in up-regulation of multilineage gene expressions and affects transcriptional regulation of certain gene clusters. (A) Tissue classifications of genes that were significantly changed in expression by UNC0638 with the UniProt tissue database. See also Supplemental Table S2. (B) Gene expression profiling performed using the Broad Institute's Molecular Signatures database. Genes that were considered differentially expressed were compared with the Novartis normal tissue compendium. Multilineage genes up-regulated by UNC0638 are shown. (C,D) Clusters of genes that were significantly changed in expression by UNC0638. Looking for genes in close proximity in the differential expression set identified these clusters. The fold change represents the gene expression change between CD34+ HSPCs treated with UNC0638 compared with the DMSO control. Arrows indicate transcription directions.