FIG. 4.

Immunohistochemical localization and quantification of FSP-1-positive cells (fibroblasts) in the interstitial renal cortex. (A) Compared with the Sham (a) and L controls (b), untreated unilateral ureteral obstruction (UUO) rats had higher numbers of fibroblast-specific protein-1 (FSP1)-positive cells in the interstitium (c). Laser treatment after UUO did not decrease these numbers significantly (d). The L animals exhibited higher numbers of FSP-1-positive cells (b) than did the Sham animals (a). (B) Graph showing the FSP-1 expression of all groups. UUO elevated the numbers of interstitial FSP-1-positive cells, but intraoperative laser administration did not reduce these numbers. *p<0.001, sham versus UUO.