Table 1.
Calculated Pharmacokinetic Parameters from the Plasma Concentration–Time Profile of Hesperidin and Hesperetin-Glucuronide (Estimated as Hesperetin After the Treatment of the Plasma Samples with Beta-Glucuronidase to Convert Hesperetin-Glucuronide to Hesperetin), Following Intravenous Administration of Hesperidin at 20 mg/kg
| PK parameter | Hesperidin | Hesperetin-glucuronide |
|---|---|---|
| Half-life (h) | 6.74±0.79 | 5.16±1.56 |
| Co (μM) | 7.47±1.64 | |
| AUC last (h μM) | 4.12±0.26 | 3.99±0.43 |
| AUC inf. (h μM) | 4.92±0.38 | 4.57±0.44 |
| Vz (L/kg) | 64.58±3.70 | |
| Cl (L/h/kg) | 6.69±0.58 | |
| MRT (h) | 4.22±0.67 | 3.63±1.27 |
Noncompartmental analysis was followed for calculating PK parameters.
Values represent mean±SD (n=4).
PK, pharmacokinetic; AUC, area under the curve; Vz, volume of distribution; Cl, clearance; MRT, mean residence time; SD, standard deviation.