Table 3.
Adjusted RR and 95% CI for ovarian cancer in relation to demographic and lifestyle factors in the NIH-AARP Diet and Health Study, 1995-2006
| Histological Subtypes | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Non-cases | All Epithelial (N=849) | Serous (N=451) | Endometrioid (N=78) | Mucinous (N^38) | Clear Cell (N=27) | Other (N=255) | |||||||||||||
| N | N | RR | 95% CI | N | RR | 95% CI | N | RR | 95% CI | N | RR | 95% CI | N | RR | 95% CI | N | RR | 95% CI | |
| Race/ethnicity | |||||||||||||||||||
| White | 151,329 | 792 | 1(ref) | 425 | 1(ref) | 71 | 1(ref) | 36 | 1(ref) | 26 | 1(ref) | 234 | 1(ref) | ||||||
| Non-White | 17,213 | 57 | 0.66 | (0.50-0.86) | 26 | 0.56 | (0.38-0.84) | 7 | 0.90 | (0.42-1.97) | 2 | 0.47 | (0.11-1.94) | 1 | 0.35 | (0.05-2.60) | 21 | 0.81 | (0.52-1.26) |
| Pheterogenity= | 0.57 | ||||||||||||||||||
| Education | |||||||||||||||||||
| < High school | 51,854 | 245 | 1(ref) | 116 | 1(ref) | 27 | 1(ref) | 14 | 1(ref) | 10 | 1(ref) | 78 | 1(ref) | ||||||
| ≥ High school | 111,531 | 570 | 1.09 | (0.94-1.27) | 313 | 1.26 | (1.02-1.57) | 50 | 0.75 | (0.46-1.21) | 22 | 0.81 | (0.41-1.61) | 17 | 0.57 | (0.25-1.28) | 168 | 1.08 | (0.82-1.42) |
| Pheterogenity= | 0.11 | ||||||||||||||||||
| Body mass index (kg/m2) | |||||||||||||||||||
| < 30 | 126,173 | 617 | 1(ref) | 340 | 1(ref) | 50 | 1(ref) | 30 | 1(ref) | 21 | 1(ref) | 176 | 1(ref) | ||||||
| ≥ 30 | 37,081 | 197 | 1.15 | (0.98-1.35) | 89 | 0.95 | (0.75-1.20) | 23 | 1.64 | (1.00-2.70) | 7 | 0.76 | (0.33-1.73) | 4 | 0.66 | (0.23-1.94) | 74 | 1.53 | (1.17-2.02) |
| Pheterogenity= | 0.03 | ||||||||||||||||||
| Frequency of vigorous physical activity | |||||||||||||||||||
| Never/Rarely | 37,898 | 188 | 1(ref) | 90 | 1(ref) | 14 | 1(ref) | 14 | 1(ref) | 9 | 1(ref) | 61 | 1(ref) | ||||||
| <2 times/week | 59,319 | 291 | 0.97 | (0.81-1.17) | 157 | 1.08 | (0.83-1.40) | 32 | 1.37 | (0.73-2.56) | 12 | 0.59 | (0.27-1.27) | 10 | 0.64 | (0.26-1.57) | 80 | 0.85 | (0.61-1.19) |
| 3+ times/week | 69,386 | 362 | 0.99 | (0.83-1.18) | 198 | 1.12 | (0.87-1.44) | 31 | 1.13 | (0.60-2.13) | 12 | 0.49 | (0.22-1.06) | 8 | 0.45 | (0.17-1.17) | 113 | 0.96 | (0.70-1.31) |
| Pheterogenity= | 0.18 | ||||||||||||||||||
| Alcohol intake | |||||||||||||||||||
| 0 grams/day | 48,956 | 235 | 1(ref) | 127 | 1(ref) | 16 | 1(ref) | 6 | 1(ref) | 9 | 1(ref) | 77 | 1(ref) | ||||||
| >0 - <12 grams/day | 95,197 | 482 | 1.06 | (0.90-1.24) | 249 | 1.00 | (0.81-1.24) | 48 | 1.47 | (0.83-2.59) | 29 | 2.68 | (1.11-6.46) | 15 | 0.76 | (0.33-1.75) | 141 | 0.98 | (0.74-1.30) |
| 12 - >24 grams/day | 14,857 | 90 | 1.23 | (0.96-1.57) | 54 | 1.36 | (0.99-1.87) | 10 | 1.95 | (0.88-4.30) | 1 | 0.57 | (0.07-4.74) | 3 | 0.94 | (0.25-3.49) | 22 | 0.94 | (0.59-1.52) |
| ≥ 24 grams/day | 9,532 | 42 | 0.93 | (0.67-1.30) | 21 | 0.87 | (0.55-1.38) | 4 | 1.21 | (0.40-3.62) | 2 | 1.76 | (0.35-8.73) | 0 | 15 | 1.06 | (0.61-1.85) | ||
| Pheterogenity= | 0.53 | ||||||||||||||||||
| Smoking status | |||||||||||||||||||
| Never smoker | 73,587 | 407 | 1(ref) | 235 | 1(ref) | 34 | 1(ref) | 14 | 1(ref) | 10 | 1(ref) | 114 | 1(ref) | ||||||
| Ever smoker | 89,961 | 425 | 0.93 | (0.81-1.06) | 207 | 0.78 | (0.65-0.94) | 42 | 1.05 | (0.67-1.64) | 23 | 1.38 | (0.72-2.65) | 17 | 1.48 | (0.68-3.25) | 136 | 1.08 | (0.85-1.39) |
| Pheterogenity= | 0.19 | ||||||||||||||||||
| Former smoker | 65,701 | 327 | 0.93 | (0.81-1.08) | 155 | 0.76 | (0.62-0.93) | 35 | 1.18 | (0.73-1.89) | 18 | 1.49 | (0.74-3.00) | 13 | 1.46 | (0.64-3.35) | 106 | 1.09 | (0.84-1.42) |
| Pheterogenity= | 0.12 | ||||||||||||||||||
| Current smoker | 24,260 | 98 | 0.83 | (0.67-1.04) | 52 | 0.76 | (0.57-1.03) | 7 | 0.67 | (0.30-1.51) | 5 | 1.12 | (0.40-3.13) | 4 | 1.20 | (0.38-3.85) | 30 | 0.96 | (0.64-1.43) |
| Pheterogenity= | 0.87 | ||||||||||||||||||
† Adjusted for age (continuous), oral contraceptive use (ever/never), parity (yes/no), menopausal hormone therapy (ever/never). Unknow n/mssing set as a separate category within each factor.
‡ P value from polytomous logistic regression of case-only analysis comparing each covariate, adjusted for factors listed above.