Abstract
Spleen cells from adult BALB/c mice injected intraperitoneally with purified coxsackievirus B-3 were tested for cytotoxicity against 51Cr-labeled syngeneic infected and uninfected myofibers. Both male and female immune cells were active against uninfected targets; this reactivity was evident by day 3 of infection and persisted throughout the first week. However, we observed marked sex-related differences in immune cell cytotoxicities against infected myofibers. Males exhibited a strong T-lymphocyte response 4 to 7 days after infection. In contrast, females exhibited a weak response, and only infrequently were the immune spleen cells of females significantly more reactive against infected myofibers than against uninfected myofibers. The demonstration of a stronger effector cell response against infected myocardial cells in male mice correlates with the observation that clinical adult coxsackievirus B myocarditis and pericarditis occur predominantly in males.
Full text
PDF





Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Berjivich S., Ressel M. Effect of sex on susceptibility of adult mice to coxsackie B1 virus infection. Arch Gesamte Virusforsch. 1967;22(1):246–251. doi: 10.1007/BF01240519. [DOI] [PubMed] [Google Scholar]
- CROWELL R. L., SYVERTON J. T. The mammalian cell-virus relationship. VI. Sustained infection of HeLa cells by Coxsackie B3 virus and effect on superinfection. J Exp Med. 1961 Feb 1;113:419–435. doi: 10.1084/jem.113.2.419. [DOI] [PMC free article] [PubMed] [Google Scholar]
- GRODUMS E. I., DEMPSTER G. Myocarditis in experimental Coxsackie B-3 infection. Can J Microbiol. 1959 Dec;5:605–615. doi: 10.1139/m59-074. [DOI] [PubMed] [Google Scholar]
- Huber S. A., Job L. P., Woodruff J. F. Lysis of infected myofibers by coxsackievirus B-3-immune T lymphocytes. Am J Pathol. 1980 Mar;98(3):681–694. [PMC free article] [PubMed] [Google Scholar]
- Julius M. H., Simpson E., Herzenberg L. A. A rapid method for the isolation of functional thymus-derived murine lymphocytes. Eur J Immunol. 1973 Oct;3(10):645–649. doi: 10.1002/eji.1830031011. [DOI] [PubMed] [Google Scholar]
- Kim Y. B., Huh N. D., Koren H. S., Amos D. B. Natural killing (NK) and antibody-dependent cellular cytotoxicity (ADCC) in specific pathogen-free (SPF) miniature swine and germfree piglets. I. Comparison of NK and ADCC. J Immunol. 1980 Aug;125(2):755–762. [PubMed] [Google Scholar]
- Lerner A. M., Wilson F. M. Virus myocardiopathy. Prog Med Virol. 1973;15:63–91. [PubMed] [Google Scholar]
- Mackaness G. B., Lagrange P. H., Miller T. E., Ishibashi T. Feedback inhibition of specifically sensitized lymphocytes. J Exp Med. 1974 Mar 1;139(3):543–559. doi: 10.1084/jem.139.3.543. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Oberg B., Philipson L. Replication of poliovirus RNA studied by gel filtration and electrophoresis. Eur J Biochem. 1969 Dec;11(2):305–315. doi: 10.1111/j.1432-1033.1969.tb00774.x. [DOI] [PubMed] [Google Scholar]
- PLAGER H., BEEBE R., MILLER J. K. Coxsackie B-5 pericarditis in pregnancy. Arch Intern Med. 1962 Nov;110:735–738. doi: 10.1001/archinte.1962.03620230181024. [DOI] [PubMed] [Google Scholar]
- Ramshaw I. A., Bretscher P. A., Parish C. R. Regulation of the immune response. I. Suppression of delayed-type hypersensitivity by T cells from mice expressing humoral immunity. Eur J Immunol. 1976 Oct;6(10):674–679. doi: 10.1002/eji.1830061003. [DOI] [PubMed] [Google Scholar]
- Sainani G. S., Krompotic E., Slodki S. J. Adult heart disease due to the Coxsackie virus B infection. Medicine (Baltimore) 1968 Mar;47(2):133–147. doi: 10.1097/00005792-196803000-00003. [DOI] [PubMed] [Google Scholar]
- Smith W. G. Coxsackie B myopericarditis in adults. Am Heart J. 1970 Jul;80(1):34–46. doi: 10.1016/0002-8703(70)90035-9. [DOI] [PubMed] [Google Scholar]
- Wilson F. M., Miranda Q. R., Chason J. L., Lerner A. M. Residual pathologic changes following murine coxsackie A and B myocarditis. Am J Pathol. 1969 May;55(2):253–265. [PMC free article] [PubMed] [Google Scholar]
- Wong C. Y., Woodruff J. J., Woodruff J. F. Generation of cytotoxic T lymphocytes during coxsackievirus B-3 infection. I. Model and viral specificity1. J Immunol. 1977 Apr;118(4):1159–1164. [PubMed] [Google Scholar]
- Wong C. Y., Woodruff J. J., Woodruff J. F. Generation of cytotoxic T lymphocytes during coxsackievirus B-3 infection. III. Role of sex. J Immunol. 1977 Aug;119(2):591–597. [PubMed] [Google Scholar]
- Wong C. Y., Woodruff J. J., Woodruff J. F. Generation of cytotoxic T lymphocytes during coxsackievirus tb-3 infection. II. Characterization of effector cells and demonstration cytotoxicity against viral-infected myofibers1. J Immunol. 1977 Apr;118(4):1165–1169. [PubMed] [Google Scholar]
- Woodruff J. F., Kilbourne E. D. The influence of quantitated post-weaning undernutrition on coxsackievirus B3 infection of adult mice. I. Viral persistence and increased severity of lesions. J Infect Dis. 1970 Feb;121(2):137–163. doi: 10.1093/infdis/121.2.137. [DOI] [PubMed] [Google Scholar]
- Woodruff J. F., Woodruff J. J. Involvement of T lymphocytes in the pathogenesis of coxsackie virus B3 heart disease. J Immunol. 1974 Dec;113(6):1726–1734. [PubMed] [Google Scholar]
- Yoon J. W., Austin M., Onodera T., Notkins A. L. Isolation of a virus from the pancreas of a child with diabetic ketoacidosis. N Engl J Med. 1979 May 24;300(21):1173–1179. doi: 10.1056/NEJM197905243002102. [DOI] [PubMed] [Google Scholar]
- Yoon J. W., Onodera T., Notkins A. L. Virus-induced diabetes mellitus. XV. Beta cell damage and insulin-dependent hyperglycemia in mice infected with coxsackie virus B4. J Exp Med. 1978 Oct 1;148(4):1068–1080. doi: 10.1084/jem.148.4.1068. [DOI] [PMC free article] [PubMed] [Google Scholar]