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. 1981 Apr;32(1):68–73. doi: 10.1128/iai.32.1.68-73.1981

Sex-related differences in the pattern of coxsackievirus B-3-induced immune spleen cell cytotoxicity against virus-infected myofibers.

S A Huber, L P Job, J F Woodruff
PMCID: PMC350588  PMID: 6260687

Abstract

Spleen cells from adult BALB/c mice injected intraperitoneally with purified coxsackievirus B-3 were tested for cytotoxicity against 51Cr-labeled syngeneic infected and uninfected myofibers. Both male and female immune cells were active against uninfected targets; this reactivity was evident by day 3 of infection and persisted throughout the first week. However, we observed marked sex-related differences in immune cell cytotoxicities against infected myofibers. Males exhibited a strong T-lymphocyte response 4 to 7 days after infection. In contrast, females exhibited a weak response, and only infrequently were the immune spleen cells of females significantly more reactive against infected myofibers than against uninfected myofibers. The demonstration of a stronger effector cell response against infected myocardial cells in male mice correlates with the observation that clinical adult coxsackievirus B myocarditis and pericarditis occur predominantly in males.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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