Figure 1.
Kaplan-Meier survival analysis of aerosol-treated animals. All animals treated with 10 mg/kg IV-Cidofovir survived until the end of the study; all untreated controls died from RPX. Aerosol treatments with NanoFOVIR™ protected 50% (3/6), 83% (5/6) and 100% (6/6) of animals treated with 0.5, 1.0 and 1.75 mg/kg against lethal RPX infection. Differences are significant (p<0.05) between positive and negative controls and between untreated controls and animals treated with either 0.5, 1.0 or 1.75 mg/kg aerosol. Circles indicate termination of study.