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. 2012 Sep 8;40(21):10950–10963. doi: 10.1093/nar/gks839

Figure 4.

Figure 4.

Cluster 1082B is the sole piRNA cluster upregulated in pachytene cells lacking Alkbh1 and Tzfp. Scatterplot analysis of piRNA cluster reads annotated by small RNA sequencing. Expression of piRNA clusters in pachytene cells is plotted on a log2 scale in a pairwise comparison of wild type (y-axis) and Alkbh1−/− (A) or TzfpGTi/GTi (B) (x-axis). Clusters with a similar number of reads in the two samples line up along the center line (gray, open circles). Cluster 1082B, with a significantly higher number of reads in mutant samples than wild type, deviates noticeably from the center line (red, filled circle in (A); green, filled circle in (B)). The number of clusters presented is 4944. Dashed lines indicate the expression level in each genotype, showing an average expression level for cluster 1082B in wild type and a highly increased expression in the two mutants.