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. 2012 Sep 8;40(21):11009–11022. doi: 10.1093/nar/gks792

Figure 1.

Figure 1.

Structural overview of hIghmbp2hd and hIghmbp2hd–RNA. (A) Schematic representation of the domain arrangement in Upf1 and Ighmbp2. The helicase core region contains two RecA-like domains: domain 1A (pink) and domain 2A (wheat) and additional regulatory domains: domain 1B (green), domain 1C (cyan) and the ‘stalk’ (orange). Upf1 contains another regulatory domain, the CH domain (gray) located upstream of the helicase region while Ighmbp2 features two more another regulatory domains: a R3H domain (gray) and an AN-1 type zinc-finger domain (gray) downstream of the helicase region. Missense mutations and canonical motifs in Ighmbp2 are labeled. (B) Crystal structures of hIghmbp2hd. (C) Crystal structure of hIghmbp2hd–RNA. The coloring schemes for domains are as in (A). The bound phosphate ion and ssRNA are shown as red sphere and yellow cartoon tube, respectively.