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. 2012 Sep 18;40(21):10642–10656. doi: 10.1093/nar/gks848

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© The Author(s) 2012. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — TSS-associated chromatin signatures. (A) A TSS-associated signature based on enrichment of H3K4me3 is represented as a heatmap (yellow, high; blue, low levels of modification) and an enrichment profile showing the average modification scores across the signature. H3K4me3 tag counts (red) are shown for an instance of this signature at a human promoter locus. (B) A TSS-associated signature composed of five active histone modifications along with an example of this pattern seen at a divergent promoter locus. (C) A bivalent TSS-associated signature with three active modifications and one repressive modification (H3K27me3). Distributions of the active (red) and repressive (blue) histone modification tag counts are shown for a single promoter locus.