Figure 7.

CNE-associated chromatin signatures. (A) Distribution of FEs of CNEs for all small-sized signatures. (B) Histone modification enrichment profiles (as described for Figure 2) for a repressive signature highly enriched within CNEs. (C) Cell-type specific expression levels for genes proximal to CNEs bearing the repressive signature shown in (B). (D) Distribution of the ratios of T- or B-cell average expressions and other cell type average expressions for genes shown in (C) (observed, red; expected, grey). Observed ratios are significantly smaller than expected ratios calculated from gene expression levels randomly simulated across cell-types and tissues (P = 1.3 × 10⁻¹⁰, Mann–Whitney test).