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. 2012 Aug 8;40(21):e166. doi: 10.1093/nar/gks738

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© The Author(s) 2012. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — Dox-controlled switch off Nmyc leads to cerebellar developmental defects and syndactyly. (a) Absolute brain mass in four genotypic classes of mice. (b) Absolute cerebellar mass and ratio of cerebellar mass to total brain mass in four genotypic classes of mice. (c–h) Representative hematoxylin and eosin (H&E) staining of cerebellum from 12-week mice from three genotypic classes. c, e: control cerebellums. ML, molecular layer; PCL, Purkinje cell layer; GCL, granular cell layer. d, f: cerebellums from Nmyc^TRE/TRE:tTS mice. g, h: Folia of Nmyc^TRE/WT:tTS mouse and Nmyc^TRE/TRE:tTS mouse. (i) Dorsal and ventral views of hindlimbs of 12-week mice from different genotypic classes. (j) Dorsal and ventral 3D micro-CT reconstructions of hindlimbs. Panels c–f were magnified 4×. Scale bar is 100 µm.