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. 2012 Aug 8;40(21):e166. doi: 10.1093/nar/gks738

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© The Author(s) 2012. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 7. — Dox-regulated severity of cerebellar developmental defects. (a) Dox was added or removed from the drinking water of pregnant female mice at the indicated time points. (b–d) Absolute brain mass, absolute cerebellar mass and the ratio of cerebellar mass to total brain mass in mice exposed to dox for different durations (n = 5–9 for each genotype in the different exposure duration groups). Ratios in b and c are the ratios of total brain and cerebellar mass in Nmyc^TRE/TRE:tTS mice to the Nmyc^TRE/TRE mice with the same dox exposure. (e–k) Representative H&E staining of brain in mice exposed dox for different durations; (e′–k′) magnification of the cerebellum in e–k. e–j: brains from Nmyc^TRE/TRE:tTS mice; k: the brain of Nmyc^TRE/TRE mice. (l) Dorsal and ventral views of hindlimbs of 24-week mice from different genotypic classes with exposure to 2 mg/ml dox for 2 days since pregnancy (ANOVA; *P < 0.05; **P < 0.01; ***P < 0.001).