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. 2012 Aug 8;40(21):e166. doi: 10.1093/nar/gks738

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© The Author(s) 2012. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 8. — Analysis of Nmyc functional time window in postnatal cerebellar development. (a) Dox was added or removed from the drinking water of pregnant female mice at the indicated time points. (b–c) Absolute cerebellar mass and the ratio of cerebellar mass to total brain mass in mice exposed to dox for different durations (n = 4–6 for each genotype in the different exposure duration groups). Ratios in b are the ratios of cerebellar mass in Nmyc^TRE/TRE:tTS mice to the Nmyc^TRE/TRE mice with the same dox exposure. (d–h) Representative H&E staining of brain in mice exposed dox for different durations; (d′–h′) magnification of the cerebellum in d–h. d–g: brains from Nmyc^TRE/TRE:tTS mice; h: the brain of Nmyc^TRE/TRE mice (ANOVA; *P < 0.05; **P < 0.01; ***P < 0.001).