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. Author manuscript; available in PMC: 2012 Dec 27.
Published in final edited form as: Neuroscience. 2012 Oct 8;227:327–335. doi: 10.1016/j.neuroscience.2012.10.007

Fig. 1.

Fig. 1

Daily ethanol intake of male P rats treated for 5 days with 10 mg/kg (i.p.) GPI-1046 (n=6), 20 mg/kg (i.p.) GPI-1046 (n=8), or vehicle (ethanol naïve) (n=7). Graph represents average daily ethanol (±SEM) intake during the treatment (Days 1–5) and post-treatment periods (Days 6–8). Baseline was estimated as an average ethanol intake for the last two weeks prior to vehicle or GPI-1046 injections. One-way ANOVA analyses revealed significance difference (F>5.52, p<0.02) among control and treatments groups. Dunnett’s test analyses revealed significant reduction in ethanol intake with the higher dose of GPI-1046 (20 mg/kg, i.p.) starting Day 2 through Day 8 as compared to vehicle (ethanol naïve) groups. Moreover, the lower dose of GPI-1046 (10 mg/kg, i.p.) showed a significant reduction in ethanol intake, relative to vehicle-treated group, starting at Day 3 through Day 8 of treatment. Dunnett’s test analyses revealed significance difference in ethanol intake between both doses of GPI-1046 (10 and 20 mg/kg) from Day 3 through Day 7. (a: p<0.01, b: p<0.05, c: p<0.001.)